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Age-Related Hearing Loss: The Link between Inflammaging, Immunosenescence, and Gut Dysbiosis

GLP-1 (glucagon-like peptide-1) is a naturally occurring incretin hormone secreted by enteroendocrine L-cells in the small intestine in response to food intake, where it signals satiety to the brain through hypothalamic receptor binding, slows gastric emptying to prolong the feeling of fullness, and modulates the release of insulin and glucagon in a glucose-dependent manner that helps stabilize post-meal blood sugar without the hypoglycemia risk associated with older drug classes

Some of the limitations of Adjusted EBITDA include (i) Adjusted EBITDA does not properly reflect capital commitments to be paid in the future, and (ii) although depreciation and amortization are non-cash charges, the underlying assets may need to be replaced and Adjusted EBITDA does not reflect these capital expenditures

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